[PDF] Honey Bee Products: Preclinical and Clinical Studies of Their Anti-inflammatory and Immunomodulatory Properties | Semantic Scholar (2025)

The molecular targets and anticancer potential of propolis and its active compounds on cell survival, proliferation, metastasis, and apoptosis in cancer cells are highlighted and summarized.

This extensive review has been written to highlight honey’s applications in medicine; its composition with the most important bioactive compounds also illustrates its synergistic effect with other natural products having remarkable therapeutic properties in wound healing.

The current knowledge related to the the effects of flavonoids and other polyphenolic compounds from propolis on tumor growth and metastasizing ability is summarized, and possible molecular and cellular mechanisms involved in the modulation of inflammatory pathways and cellular processes that affect survival, proliferation, invasion, angiogenesis, and metastasis of the tumor are discussed.

This review aimed to provide an overview of current information revealing the importance of bee products in strengthening the immune system against COVID-19 and highlighted the immunomodulatory and the antiviral effects of zinc and polyphenols, which may actively contribute to improving symptoms and preventing complications caused by CO VID-19.

BP and BB nutritional qualities and health benefits make them promising candidates for further research towards diabetes and obesity treatment strategies, and their potential as natural therapeutic tools are underscoring.

The purpose of the present review is to emphasize the possible interactions between chemotherapy and RJ, or its components, in treating cancer illnesses.

This review highlights the great impact of RJ as an alternative medicine agent, with a focus on its anticancer, anti-inflammatory, and antioxidant activities, and links it to its apitherapeutic potential by discussing its composition.

Most studies reported that honey, propolis and bee bread demonstrated antibacterial properties against Gram-positive and Gram-negative bacteria, which is an attractive alternative to using natural products as antibacterial agents.

This review emphasizes the anti-inflammatory properties of RJ, particularly in relation to inflammatory diseases, such as multiple sclerosis (MS), rheumatoid arthritis (RA), and inflammatory bowel diseases (IBD).

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The current knowledge on the therapeutic effects of melittin and its detailed mechanisms of action against several inflammatory diseases including skin inflammation, neuroinflammation, atherosclerosis, arthritis and liver inflammation, its adverse effects as well as future prospects regarding the use ofmelittin are reviewed.

This review aims to provide broad yet detailed insight into the pharmaceutical prospects of bee products such as honey, propolis, bee pollen, royal jelly, bee bread, beeswax, and bee venom, in the domain of cancer and infectious disease management.

This review shed the light specifically on the bioavailability and bioaccessibility of honey polyphenols and highlight their roles in targeting inflammatory pathways in gastrointestinal tract disorders, edema, cancer, metabolic and cardiovascular diseases and gut microbiota.

This manuscript is aimed at reviewing the actual knowledge on BV components and its associated biological activities as well as the latest advances on this subject.

There is sufficient evidence to suggest that honey does indeed have immunomodulatory properties, which may at least partially explain the ability of honey to promote the healing of wounds, and more research is necessary for a more complete understanding of the immune-modulating properties of honey.

Honey is an agent able to modulate oxidative stress and has anti-proliferative, pro-apoptotic, anti-inflammatory, immune-modulatory and anti-metastatic properties, with special emphasis on the chemopreventive and therapeutic properties of honey and its major phenolic compounds in cancer.

Bee venom may be a useful treatment to anti-inflammatory therapy for periodontitis through suppression of NF-κB and AP-1 signaling pathways, and results suggest that administration of BV attenuates PgLPS-induced inflammatory responses.

According to the studies examined in this review, the administration of propolis can be useful in attenuating many aspects of clinical, macroscopic, and histological features of colitis in animal models.

This review is aimed at updating the current state of knowledge of antioxidant capacity of selected bee products, namely, propolis, bee pollen, and royal jelly, and of their potential antioxidant-related therapeutic applications.

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